Opioid-based versus opioid-sparing patient-controlled analgesia using ketorolac and nefopam after total knee arthroplasty: a randomized, double-blind, non-inferiority trial | Synapse
February 5, 2026Open Access
Opioid-based versus opioid-sparing patient-controlled analgesia using ketorolac and nefopam after total knee arthroplasty: a randomized, double-blind, non-inferiority trial
Key Points
To compare the effectiveness of opioid-sparing analgesia using ketorolac and nefopam against traditional opioid-based methods after total knee arthroplasty.
Participants receiving either opioid-based or opioid-sparing PCA.
Assessment of analgesic effectiveness and opioid consumption.
Opioid-sparing PCA provides similar pain relief compared to opioid-based PCA.
Significant reduction in opioid consumption observed in the opioid-sparing group.
Fewer drug-related adverse effects noted with the opioid-sparing approach.
Abstract
Opioid-sparing PCA with ketorolac and nefopam provides non-inferior analgesia to opioid-based PCA, while reducing opioid consumption and drug-related adverse effects after TKA.