What question did this study set out to answer?

The aim is to explore factors affecting protein solubility and to present strategies for its enhancement.

February 8, 2026Open Access

Strategies for enhancing protein solubility: methods, applications, and prospects

RCRuiqi CaoSichuan University WWWeihao WangSichuan University ZZZhiyan ZhangSichuan University

Key Points

The aim is to explore factors affecting protein solubility and to present strategies for its enhancement.
Review of molecular and environmental determinants of protein solubility
Integration of traditional and AI-driven modification strategies
Systematic framework development for protein engineering
Insights into the critical factors affecting protein solubility
Comparison of empirical and data-driven approaches for solubility enhancement
Identification of potential applications across food and pharmaceutical industries

Abstract

Controlling protein solubility is critical yet challenging for food and pharmaceutical applications. This review dissects the molecular and environmental determinants governing solubility behavior. It integrates traditional modification strategies with emerging artificial intelligence-driven approaches, emphasizing the transition from empirical trial-and-error to data-driven rational design. This work provides a systematic framework to advance protein engineering solutions across diverse industrial sectors.

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Cite This Study

Cao et al. (Thu,) studied this question.

synapsesocial.com/papers/698828010fc35cd7a8847178 https://doi.org/https://doi.org/10.1038/s41538-026-00743-5

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