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February 8, 2026npj Science of Food12 citationsOpen Access

Strategies for enhancing protein solubility: methods, applications, and prospects

RCRuiqi CaoWWWeihao WangZZZhiyan Zhang

Key Points

  • The aim is to explore factors affecting protein solubility and to present strategies for its enhancement.
  • Review of molecular and environmental determinants of protein solubility
  • Integration of traditional and AI-driven modification strategies
  • Systematic framework development for protein engineering
  • Insights into the critical factors affecting protein solubility
  • Comparison of empirical and data-driven approaches for solubility enhancement
  • Identification of potential applications across food and pharmaceutical industries

Abstract

Controlling protein solubility is critical yet challenging for food and pharmaceutical applications. This review dissects the molecular and environmental determinants governing solubility behavior. It integrates traditional modification strategies with emerging artificial intelligence-driven approaches, emphasizing the transition from empirical trial-and-error to data-driven rational design. This work provides a systematic framework to advance protein engineering solutions across diverse industrial sectors.

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Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/698828010fc35cd7a8847178https://doi.org/10.1038/s41538-026-00743-5
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Also Consider

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  1. 1Enhancing Bioavailability: A Review of Solubilization Techniques for Low-Soluble Drugs2026
  2. 2REVIEW ON SOLUBILITY ENHANCEMENT TECHNIQUES IN PHARMACEUTICAL FORMULATIONS2026
  3. 3Solubility Enhancement Strategies for Poorly Soluble Drugs: Recent Trends2026
  4. 4Quantifying Microstructure to Better Control Bioactive Compound Delivery in Protein-Based Systems from Low- to High-Solid Preparations for Improved Human Health2025
  5. 5Formulation Strategies to Enhance the Solubility of Poorly Water-Soluble Drugs and Phytochemicals: Current Advances and Challenges2026