This review investigates solubility improvement methods for poorly soluble drugs, suggesting implications for drug development.
Pharmaceutical development is severely hampered by poor drug solubility; over 40% of medications on the market and about 90% of drugs in development pipelines have inadequate solubility. Which also reduces bioavailability and therapeutic effectiveness. This review thoroughly investigates a range of methods, including physical alterations, chemical approaches, and innovative formulation techniques, for enhancing the solubility of poorly soluble drugs. Important techniques are covered in detail, including lipid-based formulations, solid dispersions, complexation with cyclodextrins, particle size reduction, and nanotechnology-based carriers. The mechanisms behind solubility enhancement, the benefits and drawbacks of each strategy, and their effects on drug absorption and clinical outcomes are also highlighted in the review. Recent developments and cutting-edge technologies that present viable ways to get around solubility-related obstacles in drug delivery are highlighted. For researchers and formulators looking to maximize drug solubility and enhance therapeutic results, this synthesis offers a useful framework.
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Varma et al. (2026) studied this question.
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