Mn-Catalyzed Hydroxyalkylation of α-Trifluoromethylstyrenes with Cyclopropanols: Facile Synthesis of δ-Trifluoromethyl-δ-Hydroxyketones

Key Points

• Investigate a new method for synthesizing δ-trifluoromethyl-δ-hydroxyketones from cyclopropanols and α-trifluoromethylstyrenes.
• Mn-catalyzed hydroxyalkylation experiment
• Utilization of cyclopropanols and α-(trifluoromethyl)alkenes
• Synthesis optimization techniques
• Successful construction of δ-trifluoromethyl-δ-hydroxyketones
• Demonstrated high efficiency in synthesis
• Concise method with simple starting materials