Mn-Catalyzed Hydroxyalkylation of α-Trifluoromethylstyrenes with Cyclopropanols: Facile Synthesis of δ-Trifluoromethyl-δ-Hydroxyketones

Zhixin Deng; Ying Tian; Jiyao Han; Tong-Yao Zhou; Dang Cheng; Xiao XIAO; Fener Chen

doi:10.1039/d5gc06095h

January 1, 2026Green Chemistry

Mn-Catalyzed Hydroxyalkylation of α-Trifluoromethylstyrenes with Cyclopropanols: Facile Synthesis of δ-Trifluoromethyl-δ-Hydroxyketones

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Key Points

Investigate a new method for synthesizing δ-trifluoromethyl-δ-hydroxyketones from cyclopropanols and α-trifluoromethylstyrenes.
Mn-catalyzed hydroxyalkylation experiment
Utilization of cyclopropanols and α-(trifluoromethyl)alkenes
Synthesis optimization techniques
Successful construction of δ-trifluoromethyl-δ-hydroxyketones
Demonstrated high efficiency in synthesis
Concise method with simple starting materials

Implication

Hydroxyalkylation produces δ-trifluoromethyl-δ-hydroxyketones, indicating effective synthesis strategies.

Abstract

δ-Trifluoromethyl-δ-hydroxyketones are challenging to construct from simple starting materials. A highly efficient, concise hydroxyalkylation has been successfully achieved, in which the cyclopropanols and α-(trifluoromethyl)alkenes can be utilized for construction of...

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Cite This Study

Deng et al. (2026) studied this question.

synapsesocial.com/papers/698979a6f0ec2af6756e76cd https://doi.org/10.1039/d5gc06095h

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Mn-Catalyzed Hydroxyalkylation of α-Trifluoromethylstyrenes with Cyclopropanols: Facile Synthesis of δ-Trifluoromethyl-δ-Hydroxyketones

Key Points

Implication

Abstract

Discussion

Cite This Study

Mn-Catalyzed Hydroxyalkylation of α-Trifluoromethylstyrenes with Cyclopropanols: Facile Synthesis of δ-Trifluoromethyl-δ-Hydroxyketones

Key Points

Implication

Abstract

Discussion

Cite This Study

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