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Among the single threshold methods, SUV4.0 is preferred regarding ease-of-use, observer variability and segmentation quality. While the multi-threshold lesion-based methods showed the a higher segmentation quality, SUV4.0 has the benefit of easy implementation, wide availability and is in-line with the currently set benchmark for lymphoma PET analysis. We identified SUV4.0 and a lesion-based method as the candidate methods preferred for further clinical performance evaluation.
Nijman et al. (Sun,) studied this question.