Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis | Synapse
February 14, 2026Open Access
Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis
Key Points
The study aims to identify molecular characteristics associated with severe bronchiolitis in children.
Used mucosal transcriptomics to assess gene expression profiles.
Focused on pediatric cases of RSV and all-cause bronchiolitis.
Analyzed the relationship between IL-36 secretion and immune response failure.
IL-36 secretion was prominently observed in severe cases.
Bronchiolitis cases showed an impaired interferon response.
Identified a link between IL-36 and life-threatening bronchiolitis.
Abstract
Mucosal transcriptomics identifies IL-36 secretion as a feature of life-threatening paediatric RSV and all-cause bronchiolitis associated with interferon response failure.