What question did this study set out to answer?

The study aims to identify molecular characteristics associated with severe bronchiolitis in children.

February 14, 2026Mucosal Immunology4 citationsOpen Access

Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis

MBMegan V.C. BarnesImperial College London SSSophie W.H. StretchImperial College London DSDawid SwiebodaImperial College London

Key Points

The study aims to identify molecular characteristics associated with severe bronchiolitis in children.
Used mucosal transcriptomics to assess gene expression profiles.
Focused on pediatric cases of RSV and all-cause bronchiolitis.
Analyzed the relationship between IL-36 secretion and immune response failure.
IL-36 secretion was prominently observed in severe cases.
Bronchiolitis cases showed an impaired interferon response.
Identified a link between IL-36 and life-threatening bronchiolitis.

Abstract

Mucosal transcriptomics identifies IL-36 secretion as a feature of life-threatening paediatric RSV and all-cause bronchiolitis associated with interferon response failure.

Ask AI

Helpful

Bookmark

View Full Paper