Pathological Insights into the Limitations of Clinical and Dermoscopic Evaluations in Monitoring Sonidegib Treatment Response for Locally Advanced Basal Cell Carcinoma: A Real-World Study

Key Points

• This research investigates the effectiveness of clinical and dermoscopic evaluations in monitoring treatment response to sonidegib for basal cell carcinoma.
• Analyzed a real-world cohort of patients with locally advanced basal cell carcinoma
• Evaluated clinical and dermoscopic assessments post-treatment
• Identified false positives in evaluations due to treatment-related changes
• Sonidegib produced a significant clinical response and was safe for patients
• Clinical and dermoscopic evaluations had considerable false positive rates
• Pathological biopsy was necessary for validating tumor clearance