Enantioselective Synthesis of Seven-Membered Bridged Biaryls via Pd-Catalyzed Asymmetric Annulative Allylic Alkylation

Key Points

• The aim is to develop a strategy for the enantioselective synthesis of seven-membered bridged biaryls.
• Utilized palladium-catalyzed asymmetric annulative allylic alkylation
• Employed o-indolizinyl N-sulfonylanilines as starting materials
• Incorporated (Z)-butene dicarbonate in the reaction
• Achieved excellent enantioselectivity in product formation
• Demonstrated broad substrate scope for diverse compounds
• Showed potential for scalability and late-stage modification