Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle | Synapse
March 3, 2026Open Access
Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle
Key Points
Depletion of atg13 causes impaired mitochondrial energy metabolism and increased oxidative stress in skeletal muscle.
Increased polarization of macrophages to the M1 inflammatory mode was observed in response to atg13 depletion.
The study employs genetic analysis demonstrating the significance of atg13 in maintaining myelin integrity and energy homeostasis.
Findings indicate that atg13 plays a critical role, highlighting the need for further investigation in related disorders.