Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

Mubaraq A Toriola; Emma Timlin; Sarojini Bulbule; Amy Reyes; Omolola Mary Adedeji; C Gunnar Gottschalk; Animesh Barua; Leggy A Arnold; Avik Roy

doi:10.1007/s00011-025-02158-6

January 27, 2026Inflammation ResearchOpen Access

Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

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Key Points

Depletion of atg13 causes impaired mitochondrial energy metabolism and increased oxidative stress in skeletal muscle.
Increased polarization of macrophages to the M1 inflammatory mode was observed in response to atg13 depletion.
The study employs genetic analysis demonstrating the significance of atg13 in maintaining myelin integrity and energy homeostasis.
Findings indicate that atg13 plays a critical role, highlighting the need for further investigation in related disorders.

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Implication

Analysis shows that ATG13 depletion leads to compromised myelin integrity in skeletal muscle, suggesting critical roles in energy metabolism and inflammation.

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Toriola et al. (2026) studied this question.

synapsesocial.com/papers/69a75a56c6e9836116a2009f https://doi.org/10.1007/s00011-025-02158-6

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Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

Key Points

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Implication

Discussion

Cite This Study

Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

Key Points

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Implication

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