Início
Explorar
nav.journalClub
Tendências
Mais
synapse
⌘+K
Idioma
Português
SHP2 regulates VEGFR2 Y1175/PLCγ signaling to impair tumor endothelial barrier stability | Synapse
March 3, 2026
Open Access
SHP2 regulates VEGFR2 Y1175/PLCγ signaling to impair tumor endothelial barrier stability
PK
Polina Kremmyda
SO
Sara Owad
SP
Sagnik Pal
See all
Key Points
Endothelial barrier stability is impaired by SHP2's regulation of VEGFR2 signaling pathway.
SHP2 negatively affects vascular permeability, emphasizing its role in tumor progression.
Analysis of PLCγ signaling indicates its involvement in the destabilization of the endothelial barrier.
This finding highlights potential avenues for targeted therapies in enhancing tumor endothelial integrity.
Read Full Paper
externally
Mark Helpful
Like
Save
Bookmark
Relay
Share
View Full Paper
Cite This Study
Copy
Kremmyda et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75b53c6e9836116a22754
https://doi.org/https://doi.org/10.1016/j.isci.2026.114784
Mark Helpful
Like
Save
Bookmark
Relay
Share
View Full Paper