Overexpression of IL‐10 in Adipose Mesenchymal Stem Cells Promotes Wound Healing in Diabetic Mice | Synapse
March 3, 2026Open Access
Overexpression of IL‐10 in Adipose Mesenchymal Stem Cells Promotes Wound Healing in Diabetic Mice
Key Points
Wound healing is significantly enhanced by adipose mesenchymal stem cells overexpressing IL-10, improving tissue repair processes.
The study found that this mechanism results in reduced inflammatory responses and greater fibroblast migration, aiding recovery.
Analyzed the effects of IL-10 on various cellular behaviors in a diabetic mouse model, showing a clear promotion of healing.
These findings imply that targeting IL-10 could benefit diabetic wound management, although further studies are needed.
Abstract
ADSCs that overexpress IL-10 promote wound healing in diabetic mice by reducing inflammatory responses, enhancing growth factor secretion, and increasing the migration of fibroblasts and epidermal cells.