Prospective Evaluation of Medication Variability in Tacrolimus Levels and Social Determinants of Health As Predictors of Gvhd in Children Undergoing Hematopoietic Stem Cell Transplant | Synapse
March 3, 2026
Prospective Evaluation of Medication Variability in Tacrolimus Levels and Social Determinants of Health As Predictors of Gvhd in Children Undergoing Hematopoietic Stem Cell Transplant
Key Points
GVHD risk is significantly associated with variability in tacrolimus levels and social determinants of health.
In this cohort, elevated tacrolimus variability was linked to a 37% increased risk of developing GVHD.
Observational analysis focused on social determinants alongside medication management in pediatric HSCT.
Findings suggest that better management of tacrolimus and understanding social factors may improve outcomes.