What does this research mean for the field?

The high-throughput single-cell multiomic platform enables simultaneous proteomics and transcriptomics analysis from the same cells, providing insights into cellular states and biomolecular networks. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to enhance our understanding of cellular diversity and function by integrating proteomics and transcriptomics at the single-cell level.

March 5, 2026Lab on a Chip1 citationsOpen Access

High-throughput single-cell proteomics and transcriptomics from same cells with a nanoliter-scale, spin-transfer approach

PDPranav DawarPacific Northwest National Laboratory LMLye Meng MarkilliePacific Northwest National Laboratory SWSarah M WilliamsPacific Northwest National Laboratory

Key Points

This research aims to enhance our understanding of cellular diversity and function by integrating proteomics and transcriptomics at the single-cell level.
Utilized a high-throughput single-cell multiomic platform.
Employed a nanoliter-scale approach for sample processing.
Analysed both proteomic and transcriptomic data from individual cells.
Identified distinct cellular states through multiomic profiling.
Provided insights into the regulatory roles of biomolecular networks.
Enhanced sensitivity and specificity in detecting protein and RNA expression levels.

Abstract

Single-cell multiomic platforms provide a comprehensive snapshot of cellular states and cell types by offering critical insights into the spatiotemporal regulation of biomolecular networks at a systems level, thereby defining...

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