What question did this study set out to answer?

The research aims to identify epigenetic changes associated with brain structural alterations in bipolar disorder.

March 7, 2026Open Access

Novel epigenetic loci identified from an epigenome-wide association study underlying brain structural changes in bipolar disorder

Key Points

The research aims to identify epigenetic changes associated with brain structural alterations in bipolar disorder.
Conducted an epigenome-wide association study
Analyzed methylation patterns related to brain structure
Proposed miR886-related methylation as a key candidate
Identified significant correlations between methylation and cortical thinning
Recommended further studies for replication and understanding mechanisms

Abstract

Epigenetic changes might play an important role in brain structural changes in BD. These multimodal findings nominate miR886-related methylation as a candidate molecular correlate of cortical thinning and warrant replication and mechanistic follow-up in larger, state-diverse cohorts.

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Authors

Hyun-Ho Yang

Incheon National University

K. J. HAN

Korea University

Youbin Kang

Korea University

Journals

Psychological Medicine

Actions

Institutions

Korea University

Incheon National University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Novel epigenetic loci identified from an epigenome-wide association study underlying brain structural changes in bipolar disorder

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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