An epigenome-wide association study identifies methylation changes related to brain structure in bipolar disorder, suggesting further investigation is needed.
Epigenetic changes might play an important role in brain structural changes in BD. These multimodal findings nominate miR886-related methylation as a candidate molecular correlate of cortical thinning and warrant replication and mechanistic follow-up in larger, state-diverse cohorts.
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Yang et al. (2026) studied this question.
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