What question did this study set out to answer?

The aim is to compare the performance of five Hi-C scaffolders using different reference genomes and assembly methods.

March 12, 2026Genome biology1 citationsOpen Access

Benchmarking Hi-C scaffolders using reference genomes and de novo assemblies

ASAakash SurPfizer (United States)WNWilliam Stafford Noble PMPeter J. MylerCenter for Infectious Disease Research

Key Points

The aim is to compare the performance of five Hi-C scaffolders using different reference genomes and assembly methods.
Compared five Hi-C scaffolders
Utilized multiple reference species
Evaluated under ideal and real-life conditions
Highlighted strengths and weaknesses of each scaffolder
Identified performance variations based on conditions

Abstract

We compare the performance of five Hi-C scaffolders using multiple reference species under both ideal and real-life conditions, thereby illuminating their strengths and weaknesses.

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