Benchmarking Hi-C scaffolders using reference genomes and de novo assemblies

Aakash Sur; William Stafford Noble; Peter J. Myler

doi:10.1186/s13059-026-03978-3

March 10, 2026Genome biologyOpen Access

Benchmarking Hi-C scaffolders using reference genomes and de novo assemblies

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Key Points

The aim is to compare the performance of five Hi-C scaffolders using different reference genomes and assembly methods.
Compared five Hi-C scaffolders
Utilized multiple reference species
Evaluated under ideal and real-life conditions
Highlighted strengths and weaknesses of each scaffolder
Identified performance variations based on conditions

Implication

Comparison reveals strengths and weaknesses of Hi-C scaffolders in different conditions.

Abstract

We compare the performance of five Hi-C scaffolders using multiple reference species under both ideal and real-life conditions, thereby illuminating their strengths and weaknesses.

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Cite This Study

Sur et al. (2026) studied this question.

synapsesocial.com/papers/69b25b1996eeacc4fcec9797 https://doi.org/10.1186/s13059-026-03978-3

View Full Paper

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Benchmarking Hi-C scaffolders using reference genomes and de novo assemblies

Key Points

Implication

Abstract

Discussion

Cite This Study

Benchmarking Hi-C scaffolders using reference genomes and de novo assemblies

Key Points

Implication

Abstract

Discussion

Cite This Study

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