Kinetic Modelling and In Vitro Release Mechanism of Levodopa from Sporopollenin-Based Microcapsules in Human Blood Plasma

Key Points

• The central aim is to analyze the in vitro release mechanism of levodopa from sporopollenin-based microcapsules.
• Conducted kinetic modelling of levodopa release.
• Utilized sporopollenin-based microcapsules for the study.
• Tested release profiles in human blood plasma.
• Demonstrated a sustained release profile of levodopa from microcapsules.
• Showed reduced frequency of dosing needed.
• Indicated potential to decrease motor complications associated with levodopa therapy.