Kinetic Modelling and In Vitro Release Mechanism of Levodopa from Sporopollenin-Based Microcapsules in Human Blood Plasma

Shwan A. Hamad; Zhila  Salam Othman; Shilan Hiwa Hama Salih; Trefa Mohmmed Abdullah

doi:10.1039/d5pm00261c

January 1, 2026RSC PharmaceuticsOpen Access

Kinetic Modelling and In Vitro Release Mechanism of Levodopa from Sporopollenin-Based Microcapsules in Human Blood Plasma

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Key Points

The central aim is to analyze the in vitro release mechanism of levodopa from sporopollenin-based microcapsules.
Conducted kinetic modelling of levodopa release.
Utilized sporopollenin-based microcapsules for the study.
Tested release profiles in human blood plasma.
Demonstrated a sustained release profile of levodopa from microcapsules.
Showed reduced frequency of dosing needed.
Indicated potential to decrease motor complications associated with levodopa therapy.

Implication

Evaluates levodopa release from microcapsules in vitro, suggesting potential for improved therapy in Parkinson's disease.

Abstract

Levodopa (LD) remains the most effective therapy for Parkinson's disease, but its short plasma half-life necessitates frequent dosing and contributes to motor complications.This study evaluated the in vitro release profile...

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Cite This Study

Hamad et al. (2026) studied this question.

synapsesocial.com/papers/69b3abb202a1e69014ccccbb https://doi.org/10.1039/d5pm00261c

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Kinetic Modelling and In Vitro Release Mechanism of Levodopa from Sporopollenin-Based Microcapsules in Human Blood Plasma

Key Points

Implication

Abstract

Discussion

Cite This Study

Kinetic Modelling and In Vitro Release Mechanism of Levodopa from Sporopollenin-Based Microcapsules in Human Blood Plasma

Key Points

Implication

Abstract

Discussion

Cite This Study

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