What does this research mean for the field?

Spatial single-cell proteotyping identifies immunotherapy-resistant features in the tumor microenvironment of metastatic non-small cell lung cancer (NSCLC). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the specific features that confer immunotherapy resistance in metastatic non-small cell lung cancer (NSCLC) using spatial single-cell proteotyping.

March 13, 2026Open Access

Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC

Key Points

To investigate the specific features that confer immunotherapy resistance in metastatic non-small cell lung cancer (NSCLC) using spatial single-cell proteotyping.
Conducted spatial single-cell proteotyping on tumor samples from metastatic NSCLC cases.
Analyzed cellular interactions within the tumor microenvironment.
Identified specific proteins associated with resistance to immunotherapy.
Found distinct immunotherapy-resistant features in the tumor microenvironment.
Identified several biomarkers linked to resistance traits.
Revealed complex cellular signaling pathways contributing to tumor adaptation.

Abstract

Osaka Cancer Society, KANAE Foundation for the Promotion of Medical Science, SGH Foundation, and YOKOYAMA Foundation for Clinical Pharmacology.

Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC

Key Points

Abstract

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