The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort

Key Points

• To evaluate the prognostic significance of ARID1A mutation and protein levels in endometrial cancer with no specific molecular profile.
• Conducted a retrospective analysis in a large Chinese cohort.
• Examined correlations between ARID1A mutation and protein expression.
• Analyzed associations with ER/PR expression and PIK3CA mutation status.
• ARID1A mutation linked to poorer progression-free survival for NSMP patients.
• ARID1A protein expression correlated significantly with ARID1A mutation status.
• Combined ARID1A mutation and other markers could refine classification of NSMP subtype.