The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort

Xinhui Yuan; Mengyuan Cai; Changmin YU; Zhengyao Zhai; Xiaoyan Zhou; Huaying Wang; Yulan Ren

doi:10.1007/s00432-026-06440-w

March 13, 2026Journal of Cancer Research and Clinical OncologyOpen Access

The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort

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Key Points

To evaluate the prognostic significance of ARID1A mutation and protein levels in endometrial cancer with no specific molecular profile.
Conducted a retrospective analysis in a large Chinese cohort.
Examined correlations between ARID1A mutation and protein expression.
Analyzed associations with ER/PR expression and PIK3CA mutation status.
ARID1A mutation linked to poorer progression-free survival for NSMP patients.
ARID1A protein expression correlated significantly with ARID1A mutation status.
Combined ARID1A mutation and other markers could refine classification of NSMP subtype.

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Implication

Retrospective analysis identifies ARID1A mutation as a biomarker for worse outcomes in NSMP endometrial cancer, suggesting potential for targeted treatment.

Abstract

ARID1A mutation was associated with worse PFS for patients with NSMP. ARID1A protein expression was significantly associated with ARID1A mutation. ARID1A mutation, with ER/PR expression and PIK3CA mutation status, could serve as the potential biomarkers to subclassify NSMP subtype and provide more precise therapeutic target.

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Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69b79df38166e15b153ab194 https://doi.org/10.1007/s00432-026-06440-w

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The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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