Homeostasis in living organisms is regulated by mechanical factors, including pressure. However, the mechanisms by which pressure influences cellular functions remain unclear, partly due to methodological limitations. Here, we describe a system capable of applying controlled hydrostatic pressure to cultured cells and of evaluating their responses. Under high-pressure conditions, we observed alterations in cell morphology, subcellular protein localization, and gene expression profiles. These findings provide new insights into pressure-induced cellular regulation and demonstrate the utility of our system as a platform for elucidating mechanobiological processes mediated by pressure stimuli.
Morimatsu et al. (Sun,) studied this question.
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