What question did this study set out to answer?

To compare microRNA profiles in subcutaneous and visceral adipose tissue of cancer patients by adiposity level.

March 25, 2026Open Access

Distinct miRNA expression profiles in subcutaneous and visceral adipose tissue of gastrointestinal cancer patients and their modulation based on adiposity level assessed by CT-scan

Key Points

To compare microRNA profiles in subcutaneous and visceral adipose tissue of cancer patients by adiposity level.
Compared SAT and VAT microRNA from gastrointestinal cancer patients.
Stratified patients by adiposity level assessed via CT-scan.
Analyzed depot-specific miRNA regulation.
VAT exhibits a higher tendency for metabolic dysregulation compared to SAT.
miR-155 is identified as a potential indicator of visceral fat remodeling.

Abstract

This is the first study comparing both SAT and VAT microRNA from the same cancer patients, stratified by adiposity assessed via CT-scan, showing depot-specific miRNA regulation. Our findings indicate that VAT is prone to metabolic dysregulation, with miR-155 emerging as a potential indicator of visceral fat remodeling.

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Distinct miRNA expression profiles in subcutaneous and visceral adipose tissue of gastrointestinal cancer patients and their modulation based on adiposity level assessed by CT-scan

Key Points

Abstract

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