Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid arthritis

Key Points

• This research aims to explore how emodin can improve rheumatoid arthritis by inhibiting ferroptosis.
• Experimental model of arthritis used to test emodin effects.
• Evaluation of ferroptosis markers, specifically GPX4 and ACSL4.
• Assessment of mitochondrial function in treated models.
• Emodin significantly reduces signs of arthritis in experimental models.
• Inhibition of ferroptosis through the GPX4/ACSL4 pathway is observed.
• Findings suggest emodin could be used alongside existing RA treatments.