Ophiopogonin D Alleviates Nonalcoholic Steatohepatitis via Ferroptosis Through AKT1/STAT3/HIF‐1α Axis

Key Points

• This research aims to explore how Ophiopogonin D influences liver fibrosis in nonalcoholic steatohepatitis through specific molecular pathways.
• Investigated the impact of Ophiopogonin D on liver fibrosis in models of nonalcoholic steatohepatitis.
• Analyzed the involvement of the AKT1/STAT3/HIF-1α signaling axis in ferroptosis regulation.
• Conducted assays to assess fibrosis levels and cell death pathways.
• Ophiopogonin D significantly reduced fibrosis in nonalcoholic steatohepatitis models.
• Regulation of ferroptosis was linked to the activation of the AKT1/STAT3/HIF-1α pathway.
• Findings suggest that targeting these pathways could be a viable therapeutic approach.