Ophiopogonin D Alleviates Nonalcoholic Steatohepatitis via Ferroptosis Through AKT1/STAT3/HIF‐1α Axis

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This research aims to explore how Ophiopogonin D influences liver fibrosis in nonalcoholic steatohepatitis through specific molecular pathways.
Investigated the impact of Ophiopogonin D on liver fibrosis in models of nonalcoholic steatohepatitis.
Analyzed the involvement of the AKT1/STAT3/HIF-1α signaling axis in ferroptosis regulation.
Conducted assays to assess fibrosis levels and cell death pathways.
Ophiopogonin D significantly reduced fibrosis in nonalcoholic steatohepatitis models.
Regulation of ferroptosis was linked to the activation of the AKT1/STAT3/HIF-1α pathway.
Findings suggest that targeting these pathways could be a viable therapeutic approach.

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Ophiopogonin D alleviates fibrosis in nonalcoholic steatohepatitis, highlighting its therapeutic potential.

OP-D may alleviate fibrosis in NASH by regulating ferroptosis via the AKT1/STAT3/HIF-1α axis.

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Li et al. (2026) studied this question.

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