What question did this study set out to answer?

To highlight the rare presentation of severe pancytopenia and anemia in Crohn's Disease and its diagnostic challenges.

March 30, 2026Open Access

Crohn's Disease Presenting With Severe Pancytopenia and Anemia: A Diagnostic Challenge

Key Points

To highlight the rare presentation of severe pancytopenia and anemia in Crohn's Disease and its diagnostic challenges.
Case report method used to describe the patient's clinical presentation and diagnostic journey.
Differentiation between Crohn's Disease and Intestinal Tuberculosis emphasized due to endemic symptoms.
Clinical and endoscopic features analyzed for accurate diagnosis.
Severe pancytopenia noted in a patient with Crohn's Disease.
Challenge in diagnosis due to symptoms overlapping with Intestinal Tuberculosis.
Findings stress the need for careful differentiation in endemic regions.

Abstract

Background: While anemia is a frequent complication of Crohn’s Disease (CD) due to chronic blood loss and malabsorption, the initial presentation of severe, non-iatrogenic pancytopenia is exceptionally rare. Furthermore, differentiating CD from Intestinal Tuberculosis (ITB) in endemic regions poses a significant diagnostic challenge due to overlapping clinical and endoscopic features.

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