March 21, 2017Open Access

Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study

Does a switched DAPT strategy prevent bleeding complications without increasing ischaemic events in patients following acute coronary syndrome?

Population

Patients following acute coronary syndrome (ACS)

Intervention

Switched dual antiplatelet therapy (DAPT) strategy

Comparator

Unchanged dual antiplatelet therapy (DAPT) strategy

Outcome

Bleeding complications and ischaemic eventssafety

Switching DAPT after ACS reduces bleeding complications without increasing the risk of ischemic events compared to an unchanged DAPT strategy.

A switched DAPT is superior to an unchanged DAPT strategy to prevent bleeding complications without increase in ischaemic events following ACS.

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European Heart Journal

Inserm

Aix-Marseille Université

Hôpital de la Timone

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