What question did this study set out to answer?

The central aim is to investigate how sulfur assimilation influences S-adenosyl-L-methionine (SAM) flux and methylation efficiency in heterologous biosynthesis.

April 5, 2026Open Access

Sulfur assimilation determines S-adenosyl-l-methionine flux for enhancing methylation efficiency in heterologous biosynthesis

Key Points

The central aim is to investigate how sulfur assimilation influences S-adenosyl-L-methionine (SAM) flux and methylation efficiency in heterologous biosynthesis.
Analyzed the impact of sulfur assimilation on SAM flux in a biosynthetic context.
Examined the first reduction step of sulfate in relation to C4 skeleton utilization.
Sulfur assimilation significantly impacts the flux of S-adenosyl-L-methionine.
The findings suggest a pathway for enhancing methylation efficiency in producing methyl-containing natural products.

Abstract

Sulfur assimilation determines S-adenosyl-L-methionine flux for enhancing methylation efficiency in heterologous biosynthesisThis study reveals that sulfur assimilation-specifically, the first reduction step of sulfate-has a determined impact on Sadenosyl-L-methionine flux compared with the C4 skeleton (activated form of L-homoserine).These findings offer a broadly applicable engineering strategy for the high-efficiency synthesis of diverse methyl-containing natural products with extensive practical applications.

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