Short‐Chain Fatty Acids Activate Myenteric Neurons and Delay Colonic Motility via Free Fatty Acid Receptors 2 and 3 in the Mouse

Key Points

• To investigate how short-chain fatty acids (SCFAs) influence myenteric neurons and colonic motility through specific receptors.
• Luminal administration of short-chain fatty acids in mice
• Observation of myenteric neuron activation
• Measurement of colonic transit times
• Analysis of receptor involvement using FFAR2 and FFAR3
• SCFAs activate myenteric neurons significantly
• Colonic motility delays observed with SCFA administration
• FFAR2 and FFAR3 receptors play a crucial role in these processes