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April 1, 2026Neurogastroenterology & MotilityOpen Access

Short‐Chain Fatty Acids Activate Myenteric Neurons and Delay Colonic Motility via Free Fatty Acid Receptors 2 and 3 in the Mouse

Preedajit Wongkrasant Laurie E. Wallace David Le Wallace K. MacNaughton Keith A. Sharkey

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Key Points

To investigate how short-chain fatty acids (SCFAs) influence myenteric neurons and colonic motility through specific receptors.
Luminal administration of short-chain fatty acids in mice
Observation of myenteric neuron activation
Measurement of colonic transit times
Analysis of receptor involvement using FFAR2 and FFAR3
SCFAs activate myenteric neurons significantly
Colonic motility delays observed with SCFA administration
FFAR2 and FFAR3 receptors play a crucial role in these processes

Implication

Experimental administration of SCFAs slows colonic transit in mice, suggesting new targets for gastrointestinal health.

Abstract

Acutely, luminal administration of SCFAs activates myenteric neurons and slows colonic transit through FFAR2 and FFAR3 receptors.

Discussion

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Cite This Study

Wongkrasant et al. (2026) studied this question.

synapsesocial.com/papers/69d1fceba79560c99a0a2aed https://doi.org/10.1111/nmo.70299

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effects of Short-Chain Fatty Acids on Gastrointestinal MotilityOriginal Research · 1997 · 151 citations
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