The aim is to evaluate whether early rotavirus vaccination increases diarrhea risk in infants exposed to tumor necrosis factor inhibitors.
Population-based cohort study of infants exposed to TNF inhibitors and rotavirus vaccine.
Comparison of diarrhea events in TNFi-exposed infants vs. non-exposed.
Evaluation of timing of vaccination relative to TNF inhibitor exposure.
No increase in diarrhea risk for infants vaccinated early while exposed to TNF inhibitors.
Findings consistent for those exposed late in pregnancy.
Supports updated vaccination recommendations for these infants.
Abstract
Eaxsrly rotavirus vaccination in TNFi-exposed infants did not increase diarrhea risk, even for those exposed late in pregnancy. Findings support early vaccination and reinforce updated recommendations.