Diarrhea events in offspring exposed to tumour necrosis factor inhibitors and rotavirus vaccine: a population-based cohort study

Key Points

• The aim is to evaluate whether early rotavirus vaccination increases diarrhea risk in infants exposed to tumor necrosis factor inhibitors.
• Population-based cohort study of infants exposed to TNF inhibitors and rotavirus vaccine.
• Comparison of diarrhea events in TNFi-exposed infants vs. non-exposed.
• Evaluation of timing of vaccination relative to TNF inhibitor exposure.
• No increase in diarrhea risk for infants vaccinated early while exposed to TNF inhibitors.
• Findings consistent for those exposed late in pregnancy.
• Supports updated vaccination recommendations for these infants.