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March 19, 2010Clinical Journal of the American Society of Nephrology676 citationsOpen Access

Performance of the Cockcroft-Gault, MDRD, and New CKD-EPI Formulas in Relation to GFR, Age, and Body Size

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WMWieneke M. MichelsDGDiana C. GrootendorstMVMarion Verduijn

Structured PICO

Does the CKD-EPI formula provide better estimation of GFR compared to MDRD and Cockcroft-Gault formulas?

I
Intervention
CKD-EPI, MDRD, and Cockcroft-Gault formulas for GFR estimation
O
Outcome
Absolute bias and accuracy of GFR estimationsurrogate

The CKD-EPI formula provides the best estimation of GFR, though its accuracy is comparable to the MDRD formula, with both being influenced by age and GFR.

Abstract

The absolute bias of all formulas is influenced by age; CKD-EPI and MDRD are also influenced by GFR. Cockcroft-Gault is additionally influenced by body weight and BMI. In general, CKD-EPI gives the best estimation of GFR, although its accuracy is close to that of the MDRD.

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Cite This Study

Michels et al. (2010) studied this question.

synapsesocial.com/papers/69d777fd5f9a1dad53490535https://doi.org/10.2215/cjn.06870909
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