Does the CKD-EPI formula provide better estimation of GFR compared to MDRD and Cockcroft-Gault formulas?
The CKD-EPI formula provides the best estimation of GFR, though its accuracy is comparable to the MDRD formula, with both being influenced by age and GFR.
The absolute bias of all formulas is influenced by age; CKD-EPI and MDRD are also influenced by GFR. Cockcroft-Gault is additionally influenced by body weight and BMI. In general, CKD-EPI gives the best estimation of GFR, although its accuracy is close to that of the MDRD.
Michels et al. (Fri,) studied this question.