What question did this study set out to answer?

The aim is to explore the effect of soluble A antigen on blood typing in the context of a haplo-identical hematopoietic stem cell transplant with graft-versus-host disease.

April 12, 2026Open Access

A case report of soluble A antigen confounding the blood type in a haplo‐identical hematopoietic stem cell transplant patient with graft‐versus‐host disease

Key Points

The aim is to explore the effect of soluble A antigen on blood typing in the context of a haplo-identical hematopoietic stem cell transplant with graft-versus-host disease.
Present a case study of a patient post-ABOi HSCT.
Use adsorption and neutralization studies.
Apply a modified elution method for antigen detection.
Persistent presence of soluble A antigen was confirmed in the patient.
Increased soluble ABO antigen levels were detected related to gut graft-versus-host disease.

Abstract

We present a case of persistent A antigen post-ABOi HSCT due to soluble A antigen of patient origin. Soluble A antigen was demonstrated using adsorption, neutralization studies, and a modified elution method previously described for Lewis antigens. This case suggests increased soluble ABO antigen in the setting of gut GVHD.

A case report of soluble A antigen confounding the blood type in a haplo‐identical hematopoietic stem cell transplant patient with graft‐versus‐host disease

Key Points

Abstract

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