Does VEGF/VPF stimulate nitric oxide release in rabbit and human endothelial cells?
VEGF/VPF stimulates NO release from rabbit and human endothelial cells, providing evidence for functional VEGF/VPF receptors on quiescent endothelium and suggesting a role in regulating baseline NO synthesis.
VEGF/VPF stimulates production of NO from rabbit and human ECs. This finding (1) constitutes inferential evidence for the presence of functional VEGF/VPF receptors on quiescent endothelium of the adult rabbit as well as human ECs and (2) supports the notion that putative maintenance functions of VEGF/VPF may include regulation of baseline synthesis and/or release of EC NO.
Zee et al. (Tue,) studied this question.