Key result
VEGF stimulates endothelial nitric oxide production, supporting a role in baseline vascular regulation.
Why the study?
The functional presence of VEGF/VPF receptors on quiescent adult rabbit and human vascular endothelium and their role in regulating baseline endothelial NO release was unclear.
Does VEGF/VPF stimulate nitric oxide release in rabbit and human endothelial cells?
Does VEGF/VPF stimulate nitric oxide release in rabbit and human endothelial cells?
VEGF/VPF stimulates NO release from rabbit and human endothelial cells, providing evidence for functional VEGF/VPF receptors on quiescent endothelium and suggesting a role in regulating baseline NO synthesis.
Suggests VEGF regulates baseline endothelial NO synthesis; animal data leave open human vascular relevance.
VEGF/VPF stimulates production of NO from rabbit and human ECs. This finding (1) constitutes inferential evidence for the presence of functional VEGF/VPF receptors on quiescent endothelium of the adult rabbit as well as human ECs and (2) supports the notion that putative maintenance functions of VEGF/VPF may include regulation of baseline synthesis and/or release of EC NO.
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Zee et al. (1997) studied this question. VEGF/VPF stimulates the production of nitric oxide from quiescent rabbit and human endothelial cells, supporting its role in regulating baseline endothelial nitric oxide synthesis.
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