Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell–based immunotherapy | Synapse
April 17, 2026
Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell–based immunotherapy
Key Points
This research aims to enhance PET/CT imaging techniques through the use of radionuclide-embedded gold nanoparticles labeled on natural killer cells.
Conjugation of gold nanoparticles with a mitochondrial localization sequence
Labeling of natural killer cells with radionuclide-embedded double-layer gold nanoparticles
Conducting PET/CT imaging to monitor NK cell dynamics
The method supports preclinical validation for immunotherapy applications
Abstract
MLS-conjugated RI-DLGNPs enable stable labeling and high-sensitivity PET/CT imaging for real-time monitoring of NK cells, supporting further preclinical validation for immunotherapy applications.