October 16, 2023Open Access

LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2

FWFan WangWannan Medical College YHYuhang HuCixian People's Hospital HWHongda WangUniversity of Science and Technology of China

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Abstract

This study identified an important role of the FTO-IT1/FTO axis mediated m6A modification of glycolytic genes contributed to glycolysis and tumorigenesis of HCC, and FTO-IT1 might be served as a new therapeutic target for HCC.

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