What question did this study set out to answer?

The aim is to develop a portable platform for the rapid and quantitative detection of N¹-methyladenosine (m¹A) modifications.

April 22, 2026

Integration of a Screening-Guided Near-Infrared Aptasensor into a Portable Platform for Quantitative On-Site Detection of N¹-Methyladenosine

QPQi PangZhengzhou University DZDandan ZhangZhengzhou University RMRuilin MaHainan Marine Monitoring and Forecasting Center

Key Points

The aim is to develop a portable platform for the rapid and quantitative detection of N¹-methyladenosine (m¹A) modifications.
Developed a near-infrared aptasensor for m¹A detection.
Tested the aptasensor's performance in a portable device for on-site analysis.
Employed screening-guided techniques to enhance sensitivity and specificity.
Achieved rapid detection of m¹A with high accuracy.
Demonstrated the aptasensor's effectiveness in various sample conditions.
Showed potential for integration into field applications.

Abstract

N¹-Methyladenosine (m¹A) is an important RNA modification associated with diverse biological processes and disease states, yet rapid and quantitative on-site detection of m¹A remains challenging. Herein, we report a near-infrared...

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