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This commentary discusses the role of different regulatory T cells (Tregs) in myelodysplastic syndromes (MDS) and their association with disease progression.

April 25, 2026

Not all Tregs in MDS are created equal

Key Points

This commentary discusses the role of different regulatory T cells (Tregs) in myelodysplastic syndromes (MDS) and their association with disease progression.
Analysis of findings from Vazquez et al. regarding Treg populations
Discussion of the CD95+/CD45RA− Treg subset's implications in MDS
Comparative evaluation of immunosuppressive profiles in Tregs associated with MDS progression.
CD95+/CD45RA− Tregs are linked to an immunosuppressive profile in MDS progression.
Higher frequencies of this Treg subset correlate with advanced disease stages.

Abstract

Commentary on: Vazquez et al. High frequency of CD95 + /CD45RA − regulatory T cells defines an immunosuppressive profile associated with MDS progression. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70504 .

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Authors

Mischa Selig

University of Freiburg

Livius Penter

Journals

British Journal of Haematology

Actions

Institutions

Humboldt-Universität zu Berlin

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

German Cancer Society

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Not all Tregs in MDS are created equal

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

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