Two Novel Insulin-Sensitizing Peptides MGPR and AGPAGPR from Miichthys miiuy Fish Maw Alleviate Insulin Resistance Via Regulating the PPARγ-Driven IRS1/PI3K/AKT Signaling Pathway

Key Points

• The aim is to evaluate the effects of novel peptides MGPR and AGPAGPR on insulin resistance through specific signaling pathways.
• Utilized IR-HepG2 cells and diabetic zebrafish to assess peptide efficacy.
• Investigated glucose consumption and lipid droplet formation.
• Regulation of the PPARγ-driven IRS1/PI3K/AKT signaling pathway was measured.
• MGPR and AGPAGPR significantly improved glucose consumption in IR-HepG2 cells and diabetic zebrafish.
• The peptides promoted lipid droplet formation.
• Downregulation of p-IRS-1 and GSK3β was observed, supporting their role as insulin sensitizers.