Two Novel Insulin-Sensitizing Peptides MGPR and AGPAGPR from Miichthys miiuy Fish Maw Alleviate Insulin Resistance Via Regulating the PPARγ-Driven IRS1/PI3K/AKT Signaling Pathway

Xingyan Li; Yuxiang Feng; Jianwei Huang; Siying Feng; Changchun Li; Qianqian Ouyang; Shengliang Yuan; Samad Tavakoli; Yuzhen Zhu; Menghua Wu; Luming Deng; Kefeng Wu

doi:10.1021/acs.jafc.6c00728

April 27, 2026Journal of Agricultural and Food Chemistry

Two Novel Insulin-Sensitizing Peptides MGPR and AGPAGPR from Miichthys miiuy Fish Maw Alleviate Insulin Resistance Via Regulating the PPARγ-Driven IRS1/PI3K/AKT Signaling Pathway

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Key Points

The aim is to evaluate the effects of novel peptides MGPR and AGPAGPR on insulin resistance through specific signaling pathways.
Utilized IR-HepG2 cells and diabetic zebrafish to assess peptide efficacy.
Investigated glucose consumption and lipid droplet formation.
Regulation of the PPARγ-driven IRS1/PI3K/AKT signaling pathway was measured.
MGPR and AGPAGPR significantly improved glucose consumption in IR-HepG2 cells and diabetic zebrafish.
The peptides promoted lipid droplet formation.
Downregulation of p-IRS-1 and GSK3β was observed, supporting their role as insulin sensitizers.

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Implication

Demonstrates improved glycemic control in insulin resistance models, suggesting potential for treatment.

Abstract

-GSK3β, and downregulated p-IRS-1. In IR-HepG2 cells and diabetic zebrafish, these peptides improved glucose consumption and promoted lipid droplet formation. Thus, MGPR and AGPAGPR may serve as promising natural insulin sensitizers for IR-related glycemic control.

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Li et al. (2026) studied this question.

synapsesocial.com/papers/69f2f1471e5f7920c6386fa3 https://doi.org/10.1021/acs.jafc.6c00728

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Two Novel Insulin-Sensitizing Peptides MGPR and AGPAGPR from Miichthys miiuy Fish Maw Alleviate Insulin Resistance Via Regulating the PPARγ-Driven IRS1/PI3K/AKT Signaling Pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

Two Novel Insulin-Sensitizing Peptides MGPR and AGPAGPR from Miichthys miiuy Fish Maw Alleviate Insulin Resistance Via Regulating the PPARγ-Driven IRS1/PI3K/AKT Signaling Pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

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