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August 19, 2025PLoS ONEOpen Access

Characterization of multi-targeted insulin-mimetic antidiabetic peptides using in silico approaches

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Authors

ABAnas BilalGMGhulam Mustafa

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Overview

In silico approaches revealed hypoglycemic peptides binding to key diabetic receptors, indicating potential therapeutic candidates.

Key Points

  • Peptide P2 interacted strongly with maltase-glucoamylase and glucose transporter 1, suggesting effective binding dynamics.
  • Hypoglycemic peptides from plant sources were analyzed for their binding interactions across ten diabetic protein receptors.
  • Docking studies indicated that peptides P2 and P6 exhibited superior binding patterns with significant energy scores against selected targets.
  • Findings imply that insulin-mimetic peptides may serve as therapeutic alternatives, but require further validation for clinical use.

Cite This Study

Bilal et al. (2025) studied this question.

synapsesocial.com/papers/68af4766ad7bf08b1ead499chttps://doi.org/10.1371/journal.pone.0330341
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